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Doxinate for Patients/FAQ
What causes NVP?
No one knows exactly what causes the nausea of pregnancy. Most researchers believe it’s a combination of the many physical changes taking place in your body such as the higher levels of hormones during early pregnancy.
How long will my NVP last?

For most women, NVP starts between the 4th week and 8th week of pregnancy and ends between the 12th and 16th week. However, NVP can last longer, for some up to the very end of pregnancy period.

When does NVP generally occur during the day?
Occurrence and severity of NVP varies from woman to woman.
How common is NVP?
NVP is very common. Nearly 80% of pregnant women suffer from this medical condition
Will NVP affect my baby?
Your baby’s health may get affected only if you lose too much weight and your health is compromised. Hence it is important that you speak with your healthcare professional about your NVP
Does Doxinate help to reduce impact of NVP
Doxinate is indicated in cases of nausea and vomiting of pregnancy.
Commonly, when administered at the early stage of nausea and/or vomiting, Doxinate help to prevent the condition to progress to a more serious level called hyperemesis gravidarum (HG) that requires hospitalization to rehydrate the patient.

In general, when administered at the early stage of nausea and/or vomiting, Doxinate alleviates the symptoms of NVP while improving quality of life and the ability to conduct activities of daily living.

Is Doxinate safe?
Over the years, Doxinate has been recognized as the drug of choice for NVP by the medical community: SOGC (Society of Obstetricians and Gynaecologists of ), MOTHERISK (Hospital for Sick Children, Toronto), Reprotox, NORD (National Organization for Rare Disorders). Doxinate, a combination of doxylamine succinate (antihistamine/antiemetic) and pyridoxine hydrochloride (vitamin B6), has been available in  India  from Svizera Healthcare for over 25 years. This combination has been prescribed to over millions women.
  • Doxinate is the most studied medicine for use during pregnancy. Its vitamin B6 and antihistamine combination has been included in 25 epidemiological studies (200,000 women) and 2 meta-analyses. All confirmed Doxinate's safety and efficacy in pregnancy no matter how early and for how long it is taken during pregnancy.
  • Doxinate scored the highest safety rating "A" in Briggs' Reference Guide to Fetal and Neonatal Risk.
  • Doxinate does not increase a woman's baseline risk of having a child with a major malformation.
  • Doxinate is a delayed released tablet. It normally takes between 4 to 6 hours for Doxinate to reach its optimal effect.
  • If taken only when needed, it will take a few hours before symptoms improve because of the delayed release action.
It is also important to take Doxinate on a daily basis and to take the prescribed dosing in order to reach its optimal effect. It takes 2 to 3 days of treatment with Doxinate before blood concentration of Doxinate reaches a certain level (steady state) that allows a control over a 24-hour period.
When and how should I stop using Doxinate?
You should not stop taking Doxinate on your own. Always consult your doctor or healthcare professional before changing the dosage of your prescription. If he/she decides your condition requires less or no more Doxinate, he/she will gradually reduce your dose to prevent a sudden return of your symptoms.
Can I take Doxinate with food?
The delay in action may be prolonged when tablets are taken with food. It may take up to 5 more hours before it gets effective. So instead of taking 4 to 6 hours, it may take between 9 to 11 hours before it works.
How long does drowsiness last after Doxinate has been started?
No specific study has been made on that topic. But we can assume that depending on the customer's metabolism rate, her body will eventually adjust to the substance. Therefore, drowsiness may last from 4 days to two weeks.
Is there an interaction between Doxinate and Folic Acid? Does it make too much of vitamin B6?
It would be very surprising that any reaction occurs. Vitamin B6 is water-soluble; the excess would be eliminated through urine. Taking both products together should not be a problem.
I should deliver in a couple of weeks and I would like to know if it is safe to take it so close to delivery?
Doxinate is indicated to treat NVP at any trimester of pregnancy and it has been shown to be safe in all three trimesters.

Doxinate has been included in over 30 studies and has been shown to be safe for the baby, no matter how early and for how long a woman takes it during her pregnancy. Doxinate has been rated the highest safety score (A) in Briggs' Reference Guide to Fetal and Neonatal Risk. No withdrawal symptoms are found with Doxinate as would be found in newborns of moms using cocaine during pregnancy, for example.

Doxinate should gradually be reduced instead of stopping it all of a sudden. The reason for that is only because we want to prevent a sudden return of symptoms of NVP.
Is it ok to take Doxinate while breastfeeding?
Doxinate is specifically indicated for the treatment of nausea and vomiting of pregnancy, it is therefore not indicated for lactation. There are no published reports describing the use of Doxinate during lactation. Using Doxinate during lactation is considered off-labeled use.
  • In the seventh edition of Drugs in Pregnancy and Lactation, A Reference Guide to Fetal and Neonatal Risk written by Gerald Briggs, some information is available on the use of doxylamine succinate and pyridoxine hydrochloride during lactation
  • Because of doxylamine succinate's low molecular weight, its passage into breast-milk should be expected. Effects on a nursing infant, if any, are unknown, but sedative and other antihistamine actions are a potential concern.
  • Pyridoxine is compatible with breastfeeding because it is present in low dose in the tablets so present no risk to a nursing infant.
  • The manufacturer of at least one doxylamine preparation states that doxylamine is contraindicated during lactation.
  • We do not promote the use of Doxinate during lactation, but if a physician decides to prescribe it with all this information, we believe it would be very important for the mother to monitor her baby for signs of sedation such as sleepiness.
Prescribing Doxinate for use during lactation is considered off-labelled use.
A year ago, I was prescribed Doxinate. I delivered and I am pregnant again. My Doxinate tablets are expired, what should I do?
Because the expiry date on the strip indicates that the tablets are expired, you should not take them. The special coating might have changed and the effectiveness might be altered.

As a manufacturer, we do not recommend you to take Doxinate tablets that are or may be expired for a question of safety. Even though you were diagnosed with nausea and vomiting of pregnancy (NVP) during a previous pregnancy and were prescribed Doxinate at that time, it remains very important that you consult your doctor to get a new diagnosis before you begin a treatment. We do not recommend women to begin treatment with Doxinate without a doctor's supervision. If you get a new prescription of Doxinate, the dosage and schedule will be based on your current condition.
Does Doxinate contain tartrazine?
No. To the best of our knowledge, Doxinate does not contain tartrazine. A new mention will soon be added to the Doxinate label: tartrazine free. We do not know when exactly.
Where is Doxinate sold?
Doxinate is currently available in India.
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